Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Chemical explosion, COVID-19, and environmental justice: Insights from low-cost air quality sensorsResearch article Published on 2022-11-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] addition affecting Air quality monitoring Analysis anthropogenic association Chemical Community company comparable Concentration concentrations COVID-19 Critical disaster environmental justice EPA examined finding greater Houston identify indicate Industrial fire accident information insight ITC lockdown Low-cost sensor measure MONITOR monitors objective observation Particulate matter positive protection Regulatory Sociodemographic terminal Variation [DOI] 10.1016/j.scitotenv.2022.157881 [Article Type] Research article
Rapid transition between SARS-CoV-2 variants of concern Delta and Omicron detected by monitoring municipal wastewater from three Canadian cities캐나다 3개 도시의 도시 폐수를 모니터링하여 SARS-CoV-2 변종 우려 델타와 오마이크론 간의 신속한 전환 감지Article Published on 2022-10-012022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Affect BA.1 BA.2 biases Chemical Chemical tracer collected Concentration correlation Delta demography determined by dominant Factor Government greater incidence of COVID-19 individuals introduced Lineage lineages local outbreak local outbreaks Migration MONITOR monitoring omicron pandemic plant Population Population size Prairie predominant proportion qPCR Rapid Raw influent Regulation RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant Surveillance surveillance data Treatment variant Variant of concerns variants variants of concern viral loads VoC VOCs was used wastewater Wastewater. whole-genome sequencing [DOI] 10.1016/j.scitotenv.2022.156741 PMC 바로가기 [Article Type] Article
Cheminformatics-Based Discovery of Potential Chemical Probe Inhibitors of Omicron Spike ProteinArticle Published on 2022-09-072022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, 치료제, [키워드] ACE2 Antiviral compound antiviral drug authorization bind carried Chemical Compound compounds COVID-19 COVID-19 pandemic database determine DFT drug treatment effective Emergency evaluate facilitate FDA FIVE Health human Angiotensin-converting enzyme identify IMPROVE in vitro in vivo indicated Initially Invasion less Lineage MD simulation molecular monoclonal antibody mutant neutralizing monoclonal antibody omicron Potential profile Protein protein-ligand interaction provided raised reactivity receptor reduce Reinfection Replication rising risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spread the Spike therapeutic intervention vaccination Vaccine-induced immunity variant Virtual screening virtual screening. virus virus transmission was performed [DOI] 10.3390/ijms231810315 PMC 바로가기
New Chemicals Suppressing SARS-CoV-2 Replication in Cell CultureArticle Published on 2022-09-052022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] antiviral drug binding calculated candidate Cell Cell culture Chemical Compound coronavirus cytotoxicity database derivatives develop docked docking EC50 value experiment experiments inhibit SARS-CoV-2 inhibitor inhibitors Ligand main protease molecular MPro New protease protein-ligand quantum chemistry. Replication SARS-CoV-2 SARS-CoV-2 replication selected Selection Seven solvent state suppressed Suppressing the SARS-CoV-2 university Vero E6 [DOI] 10.3390/molecules27175732 PMC 바로가기
Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical ExposuresCOVID-19 위험과 환경 화학 물질 노출의 교차점에서의 후성 유전학Review Published on 2022-09-012022-09-11 Journal: Current environmental health reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter among others Chemical contaminant COVID-19 COVID-19 susceptibility disease disrupting Drawing Endocrine Environmental chemicals Epigenetic epigenetic modification epigenetics Evidence exposure host antiviral responses host response immune pathway immune system Immunity Immunologic memory immunomodulation implicated include Infectious disease Infectious disease. Inflammation Intersection involved mechanism memory Modification molecular mechanism Numerous Pathways recent Recognition Regulation risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity Specific susceptibility the SARS-CoV-2 virus viral entry [DOI] 10.1007/s40572-022-00353-9 PMC 바로가기 [Article Type] Review
Fluorescent Platforms for RNA Chemical Biology ResearchRNA 화학 생물학 연구를 위한 형광 플랫폼Review Published on 2022-07-272022-09-11 Journal: Genes [Category] 치료제, [키워드] activities activity applied assays binding Biology Biotin change Chemical Chemical biology Clinical research clinically COVID-19 test COVID-19 tests CRISPR Degradation demonstrated detect Drug discovery drugs targeting Efficacy Efficiency efficient energy transfer ENhance enzyme Enzyme labeling example facilitate fit Fluorescence fluorescence anisotropy Fluorescence imaging fluorescent fluorescent assays. Forced In situ hybridization increase invention lAbel labeling living cells Mango microRNA miRNA movement mRNA ncRNAs non-coding RNA Non-coding RNAs Nuclease observation overcome probe Research ribonucleoprotein RNA ROI subcellular T-box tumors [DOI] 10.3390/genes13081348 PMC 바로가기 [Article Type] Review
Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking화학 측정 분석, 시험관 내 연구 및 분자 도킹과 결합된 UPLC-MS/MS를 사용하여 레드 세이지(Lantana camara L.) 품종의 항-COVID-19 바이오마커의 화학적 프로파일링 및 해명Article Published on 2022-06-122022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-COVID-19 activity. antiviral activity approach Asia Biomarker Biomarkers Brazil Candidates Chain Reaction Chemical chemometrics Compound Concentration coronavirus COVID-19 cytotoxicity Data analysis detect determine docked docking docking score E-gene Effect Efficacy except for exhibited exhibiting expression expression levels flavonoids flower followed by highest in vitro study In-vitro India infections inhibitor inhibitory activity interaction pattern Kenya Lantana Lantana camara L. cultivars leprosy Luteolin material mechanism metabolites metabolomics molecular docking multivariate Multivariate analysis Nigeria PCA PCA plot PCA plots plaque polymerase chain polymerase chain reaction principle profile progressed RdRP RdRp gene real-time RT-PCR Red Remdesivir required respiratory respiratory diseases respiratory virus respiratory viruses reverse transcription polymerase chain reaction rheumatism RNA-dependent RNA polymerase RT-PCR SARS-CoV-2 selectivity indices severe acute respiratory syndrome Coronavirus Spread spreading Structure sunset TaqMan target tested Transcription UPLC UPLC-MS/MS Verbenaceae Viral [DOI] 10.1016/j.jep.2022.115038 PMC 바로가기 [Article Type] Article
The Prevalence and Pathophysiology of Chemical Sense Disorder Caused by the Novel Coronavirus신종 코로나바이러스로 인한 화학적 감각 장애의 유병률 및 병태생리학Review Published on 2022-06-062022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme 2 receptor angiotensin-converting enzyme 2 receptor (ACE-2) article Chemical Chemical Sense chemical senses contagious coronavirus 2 coronavirus disease coronavirus variants COVID-19 described disorder dysfunction Effect enzyme global public health management mechanism morbidity novel Novel coronavirus novel coronavirus disease novel coronavirus disease (COVID-19) olfactory olfactory dysfunction pathogenic pathophysiologic pathophysiology Patient Prevalence receptor reported respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sense severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects taste dysfunction taste dysfunction. viral infection viral infections [DOI] 10.3389/fpubh.2022.839182 PMC 바로가기 [Article Type] Review
Antimicrobial use in Sweden during the COVID-19 pandemic: prescription fill and inpatient care requisition patternsCOVID-19 전염병 동안 스웨덴의 항균제 사용: 처방 조제 및 입원 환자 진료 요청 패턴Article Published on 2022-05-242022-09-11 Journal: BMC Infectious Diseases [Category] 치료제, [키워드] antibiotic Antibiotics antimicrobial antimicrobial resistance Antimicrobial stewardship Antimicrobials Antiviral Care Chemical confidence limits consequence COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic daily dose defined driver drug evaluated expected hospital increase in Increased Inpatient Linear regression OLS ordinary least square pandemic performed predict Prescriptions reduction in resulting resurgence summer Sweden. Swedish therapeutic Volume was used widespread [DOI] 10.1186/s12879-022-07405-3 PMC 바로가기 [Article Type] Article